BRAINTEASER project aims to understand if different ecological factors can affect disease phenotype and progression of patients with amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). The “Amyotrophic Lateral Sclerosis” campaign wants to bring attention to this condition and analyse the variables that might affect its progression.
In addition to genetic and epigenetic factors, environmental factors have been suggested to be significant in the causation of amyotrophic lateral sclerosis. Nevertheless, early or lifelong environmental factors as air pollutants leading to the development of ALS are not well defined. Based on the variations in incidence of ALS in different countries and continents, M. Swash and A. Eisen suggests that increasing exposure to environmental pollutants is consequently important to explain this variability in addition to genetic factors and increasing longevity.